About 13 years ago experts in virology have written in one of the most important microbiological scientific journals the following recommendation: “The presence of a large reservoir of SARS-CoV-like viruses in horseshoe bats, together with the culture of eating exotic mammals in southern China, is a time bomb. The possibility of the reemergence of SARS and other novel viruses from animals or laboratories and therefore the need for preparedness should not be ignored” (Cheng et al. 2007). Other Chinese scientists make today an explicit link between the current pandemics and unexplained pneumonia patients in the Wuhan seafood market (Xu et al. 2020). Such statements, and a lot of other sound scientific knowledge have been ignored by the public, the decision makers and the states, leading to losses of lives and an estimated global economic cost, at this moment, of about 5 trillions of dollars needed for recovery (G20 estimation), not to mention the human lives.
A problem to be solved after we get out of the current public health situation is how to improve the rationality of decision making with respect to zoonotic epidemics, how to take into account all relevant bodies of knowledge to prevent such crisis, and to better manage them when the occur.
In this text I will provide a potential research framework and a syntheses of relevant scientific information. For our scientific community and general public there are three aspects which will be probably perceived as novel (although there is nothing novel from international perspective):
- Nature and biodiversity can be not only good, but also bad, there are so called “ecosystem disservices”, of which zoonotic epidemics are an example. These disservices depend to some extent on how we manage the natural capital. The “good nature” image socially constructed after the environmental crisis has to be adjusted;
- Effective prevention of epidemics can be performed only by a multidisciplinary monitoring and research.
- Efficient reactive management (control) of epidemics can be done only by integrated assessment of public health, economic social and defense risks, there is not one single most important institution in this equation.
1 Potential research framework
The scheme below depicts a potential complex long-term research project involving scientists, governance institutions and other stakeholders, able to support decisions about zoonotic epidemics.
Figure 1 Overall scheme of an integrated projects with two clusters of subprojects: one dedicated to proactive prevention, and one to reactive management (control). Both of them need strong knowledge and data about ecological and human processes relevant for the dispersion and its effects at individual (organismal) and population (social) scale.
Cluster A it’s a matter of management science, governance, political science, economy, institutional analysis and development. I will not develop it, as it is outside my direct field of expertise. Cluster be is a matter of integrated long-term research and monitoring, a field similar with what is envisaged in sustainability science. Actually, while the research in sustainability science is traditionally focused on the “good nature”, here something accounting for the management of one kind of ecosystem disservices should be developed.
Potential objectives in cluster B (syntheses of relevant scientific knowledge in the next part of this text):
- Mapping hotspots of viral sharing by birds and mammals in Romania, in the frame of a process based accounting of ecosystem disservices at national scale
- Modeling the effects of habitat fragmentation and climate change on the dispersion of relevant vector species at regional and macro-regional scale
- Accounting for the management practices responsible for the increasing risk of viruses’ transfer to human populations.
- Construction of a data and knowledge transfer interface from environment and sustainability studies towards the scientific community of epidemiologist.
A full design of the research program can be done by standard project management techniques (brainstorming with inter-disciplinary teams, etc).
2 Short syntheses of relevant scientific information
As the literature is huge in each direction here I provide only a small sample of articles. In a project management framework full critical analysis of the literature in each sub-field will be a must before any decisions on the research design.
2.1. Epidemiology and causal complexity
Oosterbroek et al. (2016) “mention the linear, reductionist approaches of epidemiology and public health research in the second half of the 20th century, focusing on proximate cause-and-effect relationships.” They state that “by training, epidemiologists and public health researchers are less accustomed to studying causes within a systems context or addressing long time frames. Most health scientists will therefore not be familiar with the complex quantitative modeling approaches that are developed by ecosystem scientists”.
Nature can be both good and bad for human health, by different processes: “The relationship between biodiversity and infectious diseases is not straightforward; disease dynamics are complex and dependent on the system, which includes the infectious agents, their targets and hosts, their vectors, the environment (natural as well as technological and sociocultural), and the mechanisms and interactions connecting them” (Keune and Asmuth 2018).
“The need of prospective scenarios of health that are embedded in the socio-ecosystems is crucial“: “Integrating the various dimensions of complexity thanks to disciplines such as ecology and environmental sciences, health sciences, policies and law, we analyze retrospectively, and comparatively infectious diseases’ dynamics associated to policies, land use and biodiversity changes.” (Lajaunie et al. 2019).
2.2 Ecosystem disservices and the role of biodiversity in zoonotic epidemics
“Between 10,000 and 600,000 species of mammal virus are estimated to have the potential to spread in human populations, but the vast majority are currently circulating in wildlife, largely undescribed and undetected by disease outbreak surveillance.” (Carlson et al. 2020). “Systematic effects of biodiversity change on infectious disease could have enormous economic, public health, and conservation implications. As examples, at least 60% of all human disease agents are zoonotic in origin” (Young et al. 2016, and figure 2).
Figure 2 Left Animal hosts of HCoVs from their natural hosts (bats or rodents) to the intermediate hosts (camelids, civets, dromedary camels, pangolins or bovines), and eventually to the human population (Ye et al. 2020). Right Boxplots based on species‐level data of proportion of viruses for several species in an order that are zoonotic (Olival et al. 2015).
Birds can also be “carriers of other organisms or their propagules” spreading “disease to humans and poultry” and increasing the “incidence of human and livestock disease and death”; there is a moderately negative valuation of birds by society, at a global scale of relevance (Buij et al. 2017).
Disservices of nature like zoonotic diseases are a kind of ecosystem disservices. Despite the large scientific literature representations of ecosystem disservices are still marginal in the public opinion (Lyitimaki 2014), because of the past environmental crisis which led to an exaggerated shift towards completely positive image of the nature (socially stabilized then by political ideologies such as ecologism). There is an increasing trend for the integration of ecosystem services and disservices provided by all parts of biodiversity (for the case of plants see for instance Vaz et al. 2017). An example is provided in figure 3.
Figure 3 Two examples illustrating the complexity of ecosystem – health relationships when considering both ecosystem services and disservices (Oosterbroek et al. 2016)
2.3 Human action on nature has consequences on zoonotic diseases
“Changing climate and land use drive geographic range shifts in wildlife, producing novel species assemblages and opportunities for viral sharing between previously isolated species. In some cases, this will inevitably facilitate spillover into humans — a possible mechanistic link between global environmental change and emerging zoonotic disease” (Carlson et al. 2020). Global effects on species diversity may lead to bottom up effects on emerging diseases (figure 4). The fragmentation of natural habitats is hypothetically related to infectious disease emergence (figure 4; the real situation have to be checked in the case of each socio-ecological system).
Figure 4 Top-down effects of global changes on biodiversity and bottom-up effects on infectious diseases (Morand 2018).
Figure 5 The framework linking the different aspects of habitat fragmentation on biodiversity is related to infectious disease emergence through the two hypotheses: the “perturbation” hypothesis and the “pathogen pool diversity” hypothesis (Morand 2018).
The increase in global connectivity led to an increase in homogeneity of zoonotic diseases, i.e. in a decrease in their modularity (the extent to which countries differ from one another, figure 6).
Figure 6 Changes in the modularity of country infectious diseases (Morand 2018).
2.4 Public health management as socio-ecological management
Public health is connected with livestock and wildlife health in the case of zoonotic diseases. “As a long-term goal, public health systems can include paired human-wildlife surveillance and utilize sentinel monitoring toward pre-emption of spillover in humans. While these approaches will require upfront investments, cost-savings can be seen from more integrated and more preventive approaches that can benefit both human and animal health.” (Machalaba and Karesh 2015). In ecology and sustainability science there are already general frameworks linking the functioning of ecosystems and human health (figure 7)
Figure 7 Conceptual framework for assessment of the impact of ecosystems on human health (Oosterbroek et al. 2016)
„What is crucial is to find a relevant balance between taking into account relevant complexity in order to not exclude important factors or actors, and on the other hand, taking a pragmatic turn in order to be relevant for practical action which cannot wait for perfect understanding” (Keune and Asmuth 2018). In Romania one could adapt existing approaches for multi-objective management and „lists of potential action categories considered during each stage of pathogen emergence, with their expected level of effectiveness and confidence in that effectiveness” (e.g. Grant et al. 2017, figure 7). For the integrated implementation of such actions there is a need for institutional coordination (e.g. between the USA Fish and Wildlife Service, Department of Defense, and National Park Service, Grant et al. 2017).
Figure 8 Simplified prototype influence diagram that links potential management actions and abiotic and biotic factors affecting disease and amphibian processes (red ovals represent stochastic events, white ovals represent contributing processes) to two fundamental management objectives (from Grant et al. 2017).
The huge global and local costs of ecosytem disservices like zoonotic epidemics asks for future investments in trandisciplinary research involving epidemiologists, experts from other disciplines, decisioni makers and stekeholders. At least two cluster of sub-projects are needed: one for prevention, and one for reactive management. There exists already plenty of scientific knowledge which have to analysed, synthesized, and complemented with local research and monitoring in order to build the integrated data and knowledge systems needed for an as rational as possible decision making.
References (available for download here)
Buij R., Melman T. C. P., Loonen M. J. J. E. M., Fox A. D, 2017, Balancing ecosystem function, services and disservices resulting from expanding goose populations, Ambio, 46(S2), S301-S318
Carlson C. J., Albery G. F., Merow C., Trisos C. H., Zipfel C. M., Eskew E. A., Olival K. J., Ross N., Bansal S., 2020, Climate change will drive novel cross-species viral tranmission, bioRxiv preprint, https://doi.org/10.1101/2020.01.24.918755
Cheng V. C. C., Lau S. K. P., Woo P. C. Y., Yuen K. Y., 2007, Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection, Clinical Microbiology Reviews, 20, 660-694
Grant E. H. C., Muths E., Katz R. A., et al., 2017, Using decision analysis to support proactive management of emerging intectious wildlife diseases, Front Ecol Environ, 15: 214-221
Keune H., Assmuth T., 2018, Framing complexity in environmental and human health, Oxford Research Encyclopedia, Environmental Science, DOI: 10.1093/acrefore/9780199389414.013.350
Lejaunie C., Morand S., Mazzega P., Complexity of scenarios of future health: integrating policies and laws, 2019, in “Law, Public Policies and Complex Systems: Networks in Action”, Springer, 42, 113-131
Lyytimaki J., 2014, Bad nature: newspaper representations of ecosystem disservices, Urban Forestry & Greening, 13, 418-424
Machalaba C., Karesh W. B., 2015, Envisioning a world without emerging disease outbreaks, Solutions, 6, 63-71
Marselle M. R., Stadler J., Korn H., Irvine K. N., Bonn A., 2019, Biodiversity and Health in the Face of Climate Change, Springer Nature Switzerland AG
McFarlane R., Sleigh A., McMichael T., 2012, Synanthropy of Wild Mammals as a Determinant of Emerging Infectious Diseases in the Asian–Australasian Region EcoHealth 9, 24-35
Morand S., 2018, Biodiversity and disease transmission, in Hurst C. J. (ed.), The connections between ecology and infectious disease, Advances in Environmental Microbiology, 5, 39-56
Murray K. A., Daszak P., 2013, Human ecology in pathogenic landscapes: two hypothesis on how land use change drives viral emergence, Curr Opin Virol, 3, 79-83
Olival K. J., Weekley C. C., Daszak P., 2015, Are bats really „special” as viral reservoirs? What we know and need to know, in Wang L.-F. And Cowled C. (eds) Bats and Viruses: a New Frontier of Emerging Infectious Diseases, John Willey & Sons, Inc., 281-294
Oosterbroek B., de Kraker J., Huynen M. M. T. E., Martens P., 2016, Assessing ecosystem impacts on health: a toole review, Ecosystem Services, 17, 237-254
Shackleton C. M., Ruwanza S., Sinasson Sanni G. K., Bennet S., De Lacy P., Modipa R., Mtati N., Sachikonye M., Thondhlana G., 2016, Unpacking Pandora’s Box: Understanding and Categorising Ecosystem Disservices for Environmental Management and Human Wellbeing, Ecosystems, 19, 587-600
Vaz A. S., Kueffer C., Kull C. A., Richardson D. M., Vicente J. R., Kuhn I., Schroter M., Hauck J., Bonn A., Honrado J. P., 2017, Integrating ecosystem services and disservices: insights from plant invasions, Ecosystem services, 23, 94-107
Xu J., Zhao S., Teng T., Abdalla A. E., Zhu W., Xie L., Wang Y., Guo X., 2020, Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV, Viruses, 12, 244, doi:10.3390/v12020244
Ye Z.-W., Yuan S., Yuen K.-S., Fung S.-Y., Chan C.-P., Jin D.-Y., 2020, Zoonotic origins of human coronaviruse, Int. J. Biol. Sci., 16, 1686-1697
Young H. S., Parker I. M., Gilbert G. S., Guerra A. S., Nunn C. L., 2017, Introduced Species, Disease Ecology, and Biodiversity Disease Relationships, Trends in Ecology and Evolution, 32, 41-54
Virgil Iordache is a professor and researcher at the Faculty of Biology – University of Bucharest, where he’s been working since 1993. He has graduated in biology with a major in bio-chemistry, holds a PhD in ecotoxicology and also holds licenses in philosophy – the evolution of institutions. He is the author of many books and articles and is the manager of the Center of Research for Environmental Services at the University of Bucharest.
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